Properties of 4,4-Dimethyl-1,3-Cyclohexanedione

4,4-Dimethyl-1,3-Cyclohexanedione
CAS:562-46-9
Molecular Formula:C8H12O2
Formula Weight:140.18
Description:
Specification:5g/25g
Melting point:103-105 °C(lit.)
Boiling point:130 °C7 mm Hg(lit.)
1,4-Cyclohexanedione is the amoebic compound. This tan or chicken apparent solid is one of the three isomeric cyclohexanediones. This accurate diketone is acclimated as a architecture block in the amalgam of added circuitous molecules.
1,4-Cyclohexanedione is able in two accomplish from diesters of succinic acid. For archetype beneath basal conditions, the diethyl ester condenses to accord 2,5-dicarbethoxy-1,4-cyclohexanedione. This average can be hydrolysed and decarboxylated to allow the adapted dione
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Specifications of 2-Chloro-1,3,2-dioxaphospholane

2-Chloro-1,3,2-dioxaphospholane
Synonyms:Ethylene chlorophosphite; Ethylene glycol chlorophosphite
CAS:822-39-9
Molecular formula:C2H4ClO2P
Molecular weight:126.48
Physical Appearance: Clear Colorless Oil
Solubility: Soluble in Dichloromethane
2-Chloro-1,3,2-dioxaphospholane is a highly reactive, cyclic phosphitylating reagent that provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Phospholane is a saturated, five-membered heterocycle having four carbon atoms and one phosphorus atom; any derivative of this compound.
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Specifications of 4-Hydroxy-2-Methylacetophenone

4-Hydroxy-2-Methylacetophenone
CAS:875-59-2
Molecular Formula:C9H10O2
Formula Weight:150.17
Specification:5g/25g
Description:
Melting point:129-131 °C(lit.)
Boiling point:313 °C(lit.)
Acetophenone is the amoebic admixture with the blueprint C6H5C(O)CH3. It is the simplest ambrosial ketone. This colourless, adhesive aqueous is a forerunner to advantageous resins and fragrances.
Acetophenone can be acquired by a array of methods. In industry, acetophenone is recovered as a by-product of the blaze of ethylbenzene, which mainly gives ethylbenzene hydroperoxide for use in the assembly of propylene oxide.
Uses
Commercially cogent resins are produced from analysis of acetophenone with formaldehyde and base. The consistent polymers are frequently declared with the blueprint [(C6H5C(O)CH]x(CH2)x}n, consistent from aldol condensation. These substances are apparatus of coatings and inks. Adapted acetophenone-formaldehyde resins are produced by the hydrogenation of the above ketone-containing resins. The consistent polyol can be added crosslinked with diisocyanates. These adapted resins are afresh begin in coatings, inks, as able-bodied as adhesives.
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What is Flibanserin used for?

Flibanserin (BIMT-17; proposed barter name Girosa) is a biologic that was advised by Boehringer Ingelheim as a novel, non-hormonal analysis for pre-menopausal women with Hypoactive Animal Admiration Ataxia (HSDD). Development was concluded in October 2010 afterward a abrogating address by the U.S. Food and Biologic Administration.
HSDD is the a lot of frequently appear changeable animal complaint and characterized by a abatement in animal admiration that causes apparent claimed ache and/or claimed difficulties. According to prevalence studies about 1 in 10 women appear low animal admiration with associated distress, which may be HSDD. The neurobiological alleyway of changeable animal admiration involves interactions a part of assorted neurotransmitters, sex hormones and assorted psychosocial factors. Animal admiration is articulate in audible academician areas by a antithesis amid inhibitory and excitatory neurotransmitters, serotonin acting as an inhibitor while dopamine and norepinephrine act as a stimulator of animal desire.  Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor adversary that had initially been advised as an antidepressant. Preclinical affirmation appropriate that flibanserin targets these receptors preferentially in careful academician areas and helps to restore a antithesis amid these inhibitory and excitatory effects. HSDD has been accustomed as a audible animal action ataxia for added than 30 years.
The proposed apparatus of action refers aback to the Kinsey bifold ascendancy model. Several sex steroids, neurotransmitters, and hormones accept important excitatory or inhibitory furnishings on the animal response. A part of the neurotransmitters, the excitatory action is apprenticed by dopamine and norepinephrine, while the inhibitory action is apprenticed by serotonin. The antithesis amid these systems is accordant for a advantageous animal response. By modulating these neurotransmitters in careful academician areas, flibanserin, a 5-HT1A receptor agonist and 5-HT2A receptor antagonist, is acceptable to restore the antithesis amid these neurotransmitter systems.
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Specifications of 2-Chloro-N,N-dimethylacetamide

2-Chloro-N,N-dimethylacetamide
CAS:2675-89-0
Molecular Formula:C4H8ClNO
Formula Weight:121.57
Specification:1g/250mg
Description:
Flashing point:98-100°C/11mm
Boiling point:98-100°C/11mm
Acetamide (IUPAC: ethanamide) is an amoebic admixture with the blueprint CH3CONH2. It is the simplest amide acquired from acerb acid. It finds some use as a plasticizer and as an automated solvent. The accompanying admixture N,N-dimethylacetamide (DMA) is added broadly used, but it is not able from acetamide.
Acetamide has been detected abreast the centermost of the Milky Way galaxy. This award is potentially cogent because acetamide has an amide bond, agnate to the capital band amid amino acids in proteins. This award lends abutment to the approach that amoebic molecules that can advance to activity (as we apperceive it on Earth) can anatomy in space.
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What is 1,4,7,10-Tetraazacyclododecane,cyclen?

Cyclen or 1,4,7,10-tetraazacyclododecane is a macrocycle and the aza alternation of the acme ether 12-crown-4. Derivatives of cyclen are beyond circadian polyamines but the repeating assemblage (ethyleneimine) is consistently the same. Like acme ethers, cyclen compounds are able of selectively bounden cations. They are acclimated as a ligand in allure for instance with chemicals acclimated in MRI adverse agents.
1,4,7,10-tetraazacyclododecane compounds can be actinic by accumulation two abstracted locations by nucleophilic displacement. In this action the terminal amine groups in diethylene triamine (1) are activated as amine anionic nucleophiles by acknowledgment with tosyl chloride in pyridine to the N-tosyl careful accumulation followed by proton absorption with sodium ethoxide. The booze end groups in diethanolamine (2) are activated as electrophile by converting them into tosyl abrogation groups. The two segments are abutting in dimethylformamide and unless the reactants are actual diluted, accustomed polymerization will yield abode to continued beeline chains and not cyclization. In the final footfall the tosyl groups are removed with sulfuric acid.
High concoction altitude aftereffect in a low acknowledgment amount amends and this disadvantage is removed in an another action starting from triethylenetetraamine and dithiooxamide to a bisamidine (also a bis(imidazoline)) followed by abridgement and ring amplification with DIBAL.
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Specifications of Tetramethylammonium fluoride

Tetramethylammonium fluoride
CAS:373-68-2
Molecular Formula:C4H12FN
Formula Weight:93.14
Specification:1g/5g
Description:
Melting point:170°C (dec.)
Ammonium fluoride is the asleep admixture with the blueprint NH4F. It crystallizes as baby colourless prisms, accepting a aciculate acrid taste, and is awfully acrid in water.
Ammonium fluoride adopts the wurtzite clear structure, in which both the ammonium cations and the fluoride anions are ample in ABABAB... layers, anniversary getting tetrahedrally amidst by four of the other. There are NH...F hydrogen bonds amid the anions and cations. This anatomy is actual agnate to ice, and ammonium fluoride is the alone actuality which can anatomy alloyed crystals with water.
Uses
This actuality is frequently alleged "commercial ammonium fluoride". The chat "neutral" is sometimes added to "ammonium fluoride" to represent the aloof alkali - [NH4]F vs the "acid salt" (NH4HF2). The acerbic alkali is usually acclimated in alternative to the aloof alkali in the carving of bottle and accompanying silicates. This acreage is aggregate a part of all acrid fluorides. For this acumen it cannot be handled in bottle analysis tubes or accoutrement during class work.
It is aswell acclimated for attention wood, as a mothproofing agent, in press and dying textiles, and as an antibacterial in breweries.
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Specifications of 2-Amino-6-bromopyridine

2-Amino-6-bromopyridine
CAS Number: 19798-81-3
Molecular Weight: 173.01
Molecular Formula: C5H5BrN2
Physical Appearance: White to tan powder
2-Amino-6-bromopyridine, employed in an efficient one-pot synthesis of 7-azaindoles. Used in the synthesis of anti-HIV agents.
When 2-aminopyridine and bromine in the anatomy of vapour adulterated with nitrogen are anesthetized over brush at 500°, a agitated acknowledgment takes place, abundant carbon is deposited and a circuitous admixture of brominated aminopyridines is formed.
isomeric monobromo-compounds could be abandoned from the mixture, i.e. 2-amino-3-bromopyridine, 2-amino-5-bromopyridine and 2-amino-6-bromopyridine. It independent added 3 dibromo-compounds (2-amino-3,5-dibromopyridine, 2-amino-3,6-dibromo-pyridine and 2-amino-5,6-dibromopyridine) and one tribromo-compound (2-amino-3,5,6-tribromopyridine).
The acknowledgment declared differs appreciably from the bromination of 2-amino-pyridine at allowance temperature, by the endure action a admixture of alone 2-amino-5-bromo-pyridine and 2-amino-3,5-dibromopyridine getting formed.
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What is 2,6-Dimethylpyridine N-oxide?

2,6-Dimethylpyridine (2,6-lutidine) is a accustomed heterocyclic ambrosial amoebic compound. It has been abandoned from the basal atom of atramentous tar and from cartilage oil. It is a dimethyl commissioned acquired of pyridine. It has been detected in decay baptize from oil shale processing sites and above creosoting facilities. 2,6-Lutidine has been evaluated for use as a aliment accretion attributable to its absurd balm if present in band-aid at actual low concentrations, about the accurate bread-and-butter has a pungent, baneful odor.
2,6-Dimethylpyridine is abominably nucleophilic, due to the steric furnishings of the two methyl groups on the ring nitrogen. It is moderately basic, with a pKa of 6.60. In amoebic synthesis, 2,6-lutidine is appropriately broadly acclimated as a sterically hindered balmy base.
Though pyridine is an accomplished antecedent of carbon, nitrogen, and activity for assertive microorganisms, methylation decidedly retards abasement of the pyridine ring. 2,6-Lutidine was begin to be decidedly added aggressive to microbiological abasement than any of the picoline isomers or 2,4-lutidine in soil. Significant volatilization accident was empiric in aqueous media. Estimated time for complete abasement was > 30 days.
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Properties of 4,4-Dimethyl-2-Pentanone

Pentan-2-one or 2-pentanone or methyl propyl ketone is a achromatic aqueous ketone with an odor akin that of acetone. Its blueprint is C5H10O. It is sometimes acclimated in actual baby amounts as a accretion aliment additive. Two added ketones, 3-pentanone and methyl isopropyl ketone are isomers of 2-pentanone.
Chemical Properties
colourless liquid
General Description
A bright achromatic aqueous with the odor of barb polish. Flash point 45°F. Less close than baptize and acrid in water. Hence floats on water. Density 0.809 g / cm3. Vapors added than air.
Air & Baptize Reactions
Highly flammable. Acrid in water.
2-Pentanone is adverse with acerbic agents, able bases and abbreviation agents. Reacts berserk with bromine trifluoride.
2-Pentanone inhibited both prostaglandin assembly and COX-2 protein announcement in animal colon blight cells. A absorption of 400 mumol/l 2-pentanone inhibited the prostaglandin assembly by 56.9+/-12.9% which is in the aforementioned ambit as the advertence admixture NS398 (59.8+/-7.6%). The two accomplished concentrations of 2-pentanone were added analyzed by Western blot, and 400 micromol/l and 200 micromol/l 2-pentanone resulted in a 53.3+/-9.6% and +/-27.1% abridgement of the COX-2 protein levels respectively. Added studies on flavouring compounds, for archetype 2-pentanone, as colon blight chemopreventives would be actual valuable, and such after-effects may accord to approaching comestible recommendations.
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