What is MyD88 Homodimerization Inhibitory Peptide Set?

Pepinh-MYD is a 26 aa peptide that blocks MyD88 signaling by inhibiting its homodimerization through binding. Pepinh-MYD contains a arrangement from the MyD88 TIR homodimerization area (RDVLPGT) preceeded by a protein transduction arrangement (RQIKIWFQNRMKWKK) acquired from antennapedia which enables the peptide to translocate through the corpuscle film. Pepinh-MYD is provided with Pepinh-Control, a ascendancy peptide.
Myeloid differentiation primary response gene (88) (MYD88) is a protein that, in humans, is encoded by the MYD88 gene
Function
The animal ortholog MYD88 seems to action analogously to mice, back the immunological phenotype of animal beef amiss in MYD88 is agnate to beef from MyD88 amiss mice. However, accessible affirmation suggests that MYD88 is disposable for animal attrition to accepted viral infections and to all but a few pyogenic bacterial infections, demonstrating a above aberration amid abrasion and animal allowed responses.
Myd88 has been shown to interact with TLR 4, Interleukin 1 receptor, type I, RAC1, IRAK2 and IRAK1.
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