What is Sphingosine Kinase 2 (human recombinant) used for?

Formulation:
10 µg in 25 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, 0.05% Tween 20, 50% glycerol, and 3mM DTT
Description of Sphingosine Kinase 2 (human recombinant)
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate sphingolipid D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, have been identified and characterized from mammalian cells. SKs, through the formation of S1P, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis, and vascular maturation. Thus SPHKs are potential therapeutic targets for the control of cancer, inflammation, and other diseases.
Purity:>80% by SDS-PAGE
Human Sphingosine kinase 2
(GenBank Accession No. AF245447), full
length with N-terminal His tag, MW=69.5 kDa,
expressed in a Baculovirus infected Sf9 cell
expression system.
Application
Useful for the study of enzyme kinetics,
screening inhibitors, and selectivity
profiling.
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What is Sphingosine Kinase 2 (human recombinant)?

Description of Sphingosine Kinase 2 (human recombinant)
Source: human recombinant N-terminal His-tagged protein from Sf9 cells · Mr: 69.5 kDa · Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate sphingolipid D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, have been identified and characterized from mammalian cells. SKs, through the formation of S1P, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis, and vascular maturation. Thus SPHKs are potential therapeutic targets for the control of cancer, inflammation, and other diseases.
Sphingosine kinase 2, full length with N-terminal His tag, MW=74 kDa, expressed in a Baculovirus infected Sf9 cell expression system Source: Baculovirus infected Sf9 cells Fomulated in: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. Stability: >6 months at 80°C Purity: >80% by SDS-PAGE. Specific Activity: 20 U/ug. Sphingosine kinase activity was determined using D-erythrosphingosine and ATP as substrates. A unit of sphingosine kinase activity is defined as the amount of enzyme required to produce 1 pmol of S1P/min.
Applications   
useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 
More about: Sphingosine Kinase 2 (human recombinant) sale
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