Myeloid adverse primary acknowledgment gene (88) (MYD88) is a protein that, in humans, is encoded by the MYD88 gene.
Function
The animal ortholog MYD88 seems to action analogously to mice, back the immunological phenotype of animal beef amiss in MYD88 is agnate to beef from MyD88 amiss mice. However, accessible affirmation suggests that MYD88 is disposable for animal attrition to accepted viral infections and to all but a few pyogenic bacterial infections, demonstrating a above aberration amid abrasion and animal allowed responses.
MyD88 Homodimerization Inhibitory Peptide Set Functions as a decoy by binding to the MyD88 TIR domain.
MyD88 Homodimerization Inhibitory Peptide Set encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
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