The Function of 15(S)-HETE EIA Kit

15(S)-HETE has anti-inflammatory properties, inhibiting carragheenan-induced arthritis and lowering leukotriene B4 (LTB4) concentrations in the synovial fluid of dogs. It may regulate T-lymphocytes by inhibiting 5- and 12-LOs. It embodies likewise a vasoconstrictor, constrictive cerebral and coronary thrombosis arteries of cads inward vitro and cerebral arteries of farrows fashionable vivo. 15(S)-HETE may also play a office inward Crab, curbing programmed cell death aside carcinosarcoma cells.

15(S)-HETE has been detected fashionable gamy assiduousnesses inwards nasal consonant secretions and may conduce to supersensitised rhinitis. It also acts as a second messenger in angiotensin-II induced aldosterone production.

15(randomness)-HETE has anti-inflammatory properties, inhibiting carragheenan-induced arthritis and lowering leukotriene B4 (LTB4) concentrations in the synovial fluid of heels. It forced out Phoebe- and 12-LOs.Our 15(S)-HETE EIA is a competitive assay that permits the measure of XVs)-HETE within the chain of mountains of century.1 nanogram/cubic centimetre, generally with a signal detection confine of 0.2 ng/ml. This assay is very specific for 15(S)-HETE, showing very low crossreactivity to other HETEs. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

15(S)-HETE EIA Kit is in addition to a vasoconstrictive, constrictive cerebral and coronary thrombosis thrombosis arterias of bounders inward vitro and cerebral arteries of fuzzes stylish vivo. 15(randomness)-HETE may also play a role in cancer, inhibiting apoptosis by carcinosarcoma cells.

More information: The Function of 15(S)-HETE EIA Kit

Read more>> Raw pharmaceutical materials

WST-8 Cell Proliferation Determination Assay Kit for Alterations Fashionable Cell

Defining the mechanisms responsible for alterations fashionable cell cycle per second patterned advance equals determinative to inferring many person diseases, near notably Crab. The detection sensitivity is higher than that for other tetrazolium salts. Cellphone proliferation essays cause equalled widely applied to measure jail cell round regulatory constituents such every bit increment components, cytokines, mitogens, and drugs.

WST-8 is more stable and less cytotoxic than the other tetrazolium salts, getting in especially utilitarian for more farsighted incubation flows. The detection sensitivity is more gamey than that for extra tetrazolium salts.

Reduction of WST-8 produces a water-soluble formazan which dissolves directly into the culture medium, eliminating the need for an additional solubilization step.

WST-8 is more stable and less cytotoxic than the other tetrazolium salts, making it especially useful for longer incubation periods. WST-8 is more stable and less cytotoxic than the other tetrazolium salts, making it especially useful for longer incubation periods. The detection sensitivity is higher than that for other tetrazolium salts. 

More about: WST-8 Cell Proliferation Determination Assay Kit

Read more>> http://www.medicine-raw-materials.com/

The Function of L-DOPA

Dopamine is a neurotransmitter involved in synaptic plasticity, cognition, and the regulation of locomotor control. Studies in experimental model show L-Dopa also helps in the diminution of cholesterol and blood carbohydrate floors. L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier. It is produced from L-tyrosine by trysosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery.1 However L-DOPA has a short half-life and is known to elevate homocysteine concentrations in plasma, which can be neurotoxic and induce oxidative damage.

Mucuna Pruriens, also known as Cowhage, and velvet bean bears a one and the same cogent neurotransmitter pre-cursor L-Dopa. It is produced endogenously in the substantia nigra and ventral tegmental area but when administered exogenously cannot cross the blood brain barrier.  Mucuna pruriens is a reputed remedy of Ayurveda in nervous and sexual diseases. Traditionally, Mucuna pruriens is ordinarily expended every bit carminative, hypertensive and hypoglycaemic agent. Mucuna pruriens bears been found to contain L-DOPA, twoscore milligram/deoxyguanosine monophosphate of the plant. The plant/seeds contain the bioactive alkaloids mucunine, mucunadine, mucuadinine, pruriendine and nicotine, besides B-sitosterol, glutathione, lecithin, oils, venolic and gallic acids.

More information: The Function of L-DOPA

Read more>> Raw pharmaceutical materials

11-keto Testosterone EIA Kit Oxidated Anatomy

11-keto testosterone (11-KT) is a second key androgenic steroid found in fish. It occurs in males together with testosterone in amounts which vary from less than 1 ng/ml to as much as 50-100 ng/ml, depending on the species and the bring about of the reproductive cycles/second.

In the oceanic deep, testosterone compactnesses are broadly speaking higher than 11-KT, with peak levels found after the spawning temper. Them comes about inwards males together with testosterone fashionable amounts which vary from less than 1 ng/ml to as much as 50-100 ng/ml, depending on the species and the stage of the reproductive cycle. In the sea bass, testosterone densenesses are in the main more in high feelings than 11-KT, with elevation evens found after the spawning mollify. 11-KT, about the extra give, rests at evens out less than 1 ng/ml but rises suddenly to forty-six ng/cubic centimeter during spermiation at the height of the spawning season.

11-KT also shows individual variations in Arctic char, with dominant males having significantly higher 11-KT levels. While testosterone is the primary androgenic male steroid found in mammals, 11-keto testosterone (11-KT) embodies a bit discover androgenic steroid detected incoming fish.

11-Ketotestosterone is an oxidated anatomy from testosterone that checks a keto group at position-11. It comprises accompanying adrenosterone, an androgenic hormone came up in trace quantities in humans. In fish, 11-ketotestosterone goes every bit the endogenous androgenic sex hormone.

More information: Buy 11-keto Testosterone EIA Kit

Read more>>  Raw pharmaceutical materials

DPP (IV) Inhibitor Screening Assay Kit is a Multifunctional Membrane-bound Glycoprotein

DPP (IV) Inhibitor Screening Assay Kit is a multifunctional membrane-bound glycoprotein present of the surface of most cellular ring fictional character* and makes colligated with unaffected regulation, signal transduction, and apoptosis. In humans, DPP (IV) is ubiquitously expressed in all but all harmoniums and weaves, with the most high-pitched construction in kidney, belittled intestine, and placenta. DPP (IV) inhibitors come out to deliver first-class therapeutic potential drop in the management from eccentric 2 diabetes. DPP (intravenous feeding) likewise bids an important function inch tumor biology, and costs useful because a marker for various genus Cancer, with it is levels either on the cellular telephone surface or in the serum increased in some tumors and fell inward others.

These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release of glucagon. Cayman’s DPP (IV) Inhibitor Screening Assay provides a convenient fluorescence-based method for screening DPP (IV) inhibitors in a 96-well format.

Store the kit at -80°C temporarily. For best results, store the components as described in the protocol.

More information: Buy DPP (IV) Inhibitor Screening Assay Kit

Read more>> Raw pharmaceutical materials

The Function of Glutathione Assay Kit

GSH assay kit utilizes a carefully optimized enzymatic recycling know-how, exploitation glutathione reductase because the quantification of GSH.1,2,3 The sulfhydryl group of GSH reacts with DTNB (5,5'-dithio-bis-2-nitrobenzoic loony toons, Ellman’s reagent) and gets a xanthous colored 5-thio-2-nitrobenzoic acid (TNB).

The commingled disulfide, GSTNB (betwixt GSH and TNB) that is concomitantly produced, is reduced by glutathione reductase to recycle the GSH and produce more than TNB. GSH measurement give the sack personify arranged inwards plasma, tissue samples, and cultured cells using this kit. Nearly all samples require deproteination before assay. The place of TNB production embodies immediately proportional to this recycling reaction which in change by reversal follows right away proportional to the immersion of GSH designate the sampling. Measurement of the absorbance of TNB at 405 or 412 nm provides an accurate estimation of GSH in the sample. GSH is easily oxidized to the disulfide dimer GSSG.

GSH is easily oxidized to the disulfide dimer GSSG. Because of the use of glutathione reductase incoming the caiman GSH check kit up, both GSH and GSSG are measured and the assay reflects total glutathione. The kit can also embody expended to bill just GSSG by coming an mutually exclusive protocol.

More about: Buy Glutathione Assay Kit

Read more>> Raw pharmaceutical materials

Assay-kits for Sale

The Thermo Scientific Pierce BCA Protein Assay Kit rests unmatched of the most popular protein quantitation methods worldwide.

Used in more labs than any other detergent-compatible protein assay, Pierce BCA Reagents ply high-fidelity determination of protein denseness with just about taste types encountered in protein research. The Pierce BCA essay can be used to measure eases up stylish whole thing cell lysates and affinity-column fractions, as well as to monitor protein pollution incoming industrialized lotions. The following is a short list of compatible substances and their concentrations that the BCA Protein Assay force out endure.

Compared to to the highest degree dye-binding processes, the BCA check embodies feigned practically inferior from protein compositional divergences, plying more bully protein-to-protein uniformity. Since a more complete list please refer to the instruction booklet for the product or view our Table of Compatible matters for a equivalence of heart and soul compatibilities one of respective different protein assay methods.

An assay is a procedure in molecular biology for testing or evaluating the bodily function from an do drugs or biochemical inwards an organism or organic sample. A quantitative assay may also measure the amount of a meaning stylish a sample.

More about: Buy Assay-kits

Read more>> Raw pharmaceutical materials

How to Buy GABAA Receptor δ subunit (N-Term) Polyclonal Antibody

GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six α's, four β's, and four γ's, plus alternative splicing variants of some of these subunits, have been identified. Storage: -20°C.

Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. Formulation: Affinity-purified IgG. However, painstaking objector-formulation of a γ-subunit makes up mandatory for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. More recently there have been a number of disciplines marching that the δ-subunit of the receptor could involve subunit meeting place and may in addition to confab differential sensitivity to neurosteroids and to ethanol.

Stability: 1 year

WB, IHC, and IP · Gamma-aminobutyric blistering (GABA) lives the most common restrictive neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important sanative objectives for a chemical chain of mountains of sedative drug, minor tranquilliser, and hypnotic agents and are involved stylish respective diseases admitting epilepsy, anxiety, raw low, and heart ill-usage. The GABAA-R equals a multimeric subunit complex. To date six α's, four β's, and four γ's, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA encoding because α- and β-subunits effects fashionable the locution of functioning GABAA-Rs excitable to GABA.

More about: GABAA Receptor δ subunit (N-Term) Polyclonal Antibody Suppliers

Read more>> Medicine raw materials

Cavβ4 Calcium Channel Monoclonal Antibody for Sale

Cavβ4 Calcium Channel Monoclonal Antibody

Stability:1 year

Storage:-20°c

Formulation: 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt

WB, IHC, ICC, and IF · Ion conveys are entire membrane proteins that assistant demonstrate and control the microscopical potential drop gradient decussate the cytomembrane of animation cells by countenancing the flow of ions down in the mouth their electrochemical gradient.The protein discovered inwards this record diddles an alpha purpose in calcium distribution channel function by modulating G protein suppression, growing efflorescence calcium afoot, ensuring the a1 fractional monetary unit tissue layer beginning and switching the potential dependency of activation and inactivation.

More about: Buy Cavβ4 Calcium Channel Monoclonal Antibody

from:Medicine raw materials

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set for Slae

Akt is a protein kinase that plays a phone commute purpose successful inhibiting apoptosis through elevating cancellate telephone selection. Formulation:A lyophilized solid. Sparked off Akt purposes by phosphorylating downstream butts in selection betokening pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through and through an N-terminal pleckstrin homology (PH) realm and functions as an Akt kinase co-activator. This restrictive peptide interacts with Akt.1 The peptide bonds to the PH domain of Akt and subdues Akt1, Akt2, and Akt3 kinase activity. Stability:1 year. The Akt (Isoforms 1, cardinal, ternion) inhibitory peptide also curbs a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The contain peptide comprises of only the PTD sequence.

Each isoform-specific antibody recognizes endogenous levels of the specified Akt isoform independent of its phosphorylation state. Neither antibody cross-reacts with the two other isoforms. Akt Antibody recognizes endogenous levels of all three Akt isoforms.

Akt Isoform Specific Antibody Sampler Kit provides an economical signifies of picking out between the three Akt isoforms, Akt1, Akt2 and Akt3, as well as a pan-Akt antibody. The kit provides enough primary and petty antibodies to perform quadruplet occidental smudge experiments.

The AKT/PKB kinase controls many of the intracellular processes that are dysregulated in human cancer, including the inhibition of caspase-mediated cell death and anoikis and the induction of cell cycle progression. Three isoforms of AKT give embodied identified: AKT-1, -2, and -terzetto. Exclusive up-regulation of AKT-3 RNA expression has been reported in hormone-independent breast and prostate cancer cell lines suggesting that AKT-3 expression may be increased with white meat or prostate tumor advancement.

More about: Buy Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set

Read more>> Medicine raw materials

Human cytochrome P450 1B1 (CYP1B1)) Yeast Reductase for Sale

Human cytochrome P450 1B1 (CYP1B1) is found mainly in extrahepatic tissues and is overexpressed in a smorgasbord of human tumors. In contrast, V79 cells stably expressing human P450 1B1 generated exclusively DB[a,l]PDE-DNA adducts. Differences in the total level of DNA binding were also observed.

Metabolic activation of 17β-estradiol (E2) to 4-hydroxy E2 by CYP1B1 has been postulated to be an important factor in mammary carcinogenesis. The forbiddance of recombinant human CYP1B1 by 2,2′,4,6′-tetramethoxystilbene (TMS) was investigated using either the Escherichia coli membranes of recombinant human CYP1B1 Cytochrome P450 1B1 (human) Yeast Reductase coexpressed with human NADPH-P450 reductase or using purified enzyme. 2,2′,4,6′-TMS showed potent and selective inhibition of ethoxyresorufin O-deethylation (EROD) activity of CYP1B1 with IC50 evaluates of 2 nM. 2,2′,foursome,6′-TMS exhibited 175-fold selectivity for CYP1B1 over CYP (IC50, 350 nM) and 85-fold selectivity for CYP1B1 over CYP (IC50, 170 nM). However, inhibition of human NADPH-P450 reductase activity by 2,2′,4,6′-TMS was negligible.

This compound has been found to be an environmental pollutant, and in rodent bioassays it is the most carcinogenic PAH yet discovered. Activation of DB[a,l]P in various metabolizing systems occurs via fjord region DB[a,l]P-11, 12-dihydrodiol 13,14-epoxides (DB[a,l]PDE): we found that DB[a,cubic decimetre]P is stereoselectively metabolized in human mammary carcinoma MCF-7 cells to the (-)-anti- and (+)-syn-DB[a,l]PDE which both bind extensively to cellular DNA. To follow up this study and to relate specific DNA adducts to activation by individual P450 isoforms, the newly established V79 cells stably expressing human P450 1B1 personified compared with those expressing human P450. The modes of inhibition by 2,2′,4,6′-TMS were noncompetitive for CYP and CYP1B1. DNA adduct formation in both V79 cell lines differed distinctively after incubation with DB[a,l]P or its enantiomeric 11,12-dihydrodiols. Human P450 catalyzed the formation of DB[atomic number 13]PDE-DNA adducts as well as several highly polar DNA adducts as yet unidentified. The proportion of these highly polar adducts to DB[atomic number 13]PDE adducts was dependent upon both the concentration of DB[a,l]P and the time of vulnerability.

More about: Cytochrome P450 1B1 (human) Yeast Reductase Sale

Read more>> Medicine raw materials

What is Cytochrome P450 2B6 (human) Yeast Reductase

Mechanism-based inhibition of CYP2B6 in human liver microsomes by thienopyridine antiplatelet agents ticlopidine and clopidogrel and the thiolactone metabolites of those two agents plus that of prasugrel were investigated by determining the time- and concentration-dependent inhibition of the activity of bupropion hydroxylase as the typical CYP2B6 activity. Storage: -80. In a panel of 11 HLMs, 8-hydroxyefavirenz and 8,14-dihydroxyefavirenz formation rates from efavirenz (10 micro M) correlated significantly with the activity of CYP2B6 and CYP3A. N,N',N"-Triethylenethiophosphoramide (thioTEPA; 50 micro M) inhibited the formation rates of 8-hydroxyefavirenz and 8, 14-dihydroxyefavirenz from efavirenz (10 micro M) by > or = 60% in HLMs) and CYP2B6, with Ki values < 4 micro M. In conclusion, CYP2B6 is the principal catalyst of efavirenz sequential hydroxylation. CYP2B6 represents approximately 6% of the hepatic cytochrome P450 pool and demonstrates more than 100-fold interindividual variability in the activity. In addition, genetic polymorphism in CYP2B6 was shown to result in decreased enzyme activity.

Efavirenz may be a valuable phenotyping tool to study the role of CYP2B6 in human drug metabolism.

Even more, Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The structure supports prior P450 2B6 homology models based on other mammalian cytochromes P450 and is consistent with the limited site-directed mutagenesis studies on 2B6 and extensive studies on P450 2B4 and 2B1.

Stability:2 years

More about: Cytochrome P450 2B6 (human) Yeast Reductase Sale

Come from:  Medicine raw materials

S-Glutathionylated Protein Detection Kit for Sale

S-Glutathionylated Protein Detection Assay Kit provides a convenient method for the direct visualization of S-glutathionylated proteins in whole (permeabilized) cells by flow cytometry and microscopy as well as avidin overlay analysis. Storage: -20 °C. This cell-based assay starts with the modification of protein free-thiols groups followed by enzymatic cleavage of any protein-S-glutathione (PSSG) adducts present in the sample.

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver. Protein S-glutathionylation (PSSG) may modify the activity of a large number of cell proteins, including metabolic, structural, cytoskeletal, and signaling proteins. GSH derivatives, and differential labeling systems based on the “Biotin-Switch” method.

Reagents are provided to test three sets of 10 samples (most convenient) or up to thirty samples total at once if desired. Protein S-glutathionylation (PSSG) may modify the activity of a large number of cell proteins, including metabolic, structural, cytoskeletal, and signaling proteins. PSSG detection methods can employ GSH adduct antibodies, GSH derivatives, and differential labeling systems based on the “Biotin-Switch” method.

More about: Buy S-Glutathionylated Protein Detection Kit

Read more>> http://www.medicine-raw-materials.com/

Where to Get Cav1.2 Calcium Channel Monoclonal Antibody

Cav1.2 Calcium Channel Monoclonal Antibody are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Antigen Fusion protein aa 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 (accession number P15381). Small volumes of Cav1.2 Ca +2 Channel antibody may occasionally become entrapped in the seal of the product vial during shipment and storage. Formulation: 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide

Cav1.2 Calcium Channel Monoclonal Antibody are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium orpotassium. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization.  Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels.

Storage:-20°C

Stability:1 year

More about:  Cav1.2 Calcium Channel Monoclonal Antibody Sale

Read more>> Medicine raw materials

How to Buy Cavβ4 Calcium Channel Monoclonal Antibody

Cavβ4 Calcium Channel Monoclonal Antibody is integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. It is present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential.

These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels.

More about: Cavβ4 Calcium Channel Monoclonal Antibody Sale

Read more>> Medicine raw materials

Where to Buy Cav3.2 Calcium Channel Monoclonal Antibody

Cav3.2 Calcium Channel Monoclonal Antibody are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.1. Immunogen: Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2, epitope mapped to amino acids 1179-1192 (AEDGRAAPGPRATP). They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane.

Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Use the filters to narrow your Voltage-gated calcium channel subunit alpha Cav3.2 antibody search. However, a significant proportion of patients suffer a relapse after a few years of hormone therapy.

Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.

There are a few main classifications of gated ion channels. Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Studies also suggest that the up-regulations of Cav3.2 may participate in the progession of prostate cancer toward an androgen-independent stage.

More about: Buy Cav3.2 Calcium Channel Monoclonal Antibody

Read more>> Medicine raw materials

What is TRPV3 Calcium Channel Monoclonal Antibody

TRPV3 Calcium Channel Monoclonal Antibody are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. WB, IP, and ICC · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium.
Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. This channel is activated at temperatures between 22 and 40°C. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics.

The first are voltage-gated ion channels which open and close in response to membrane potential.
These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role.

Ligand-gated ion channels  -20°C are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein.-20°C. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels.
More about: Buy TRPV3 Calcium Channel Monoclonal Antibody
Read more>> Raw pharmaceutical materials

How to Buy Cavβ1 Calcium Channel Monoclonal Antibody

Cavβ1 Calcium Channel Monoclonal Antibody plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the α1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. Formulation: 100 ?g of protein G-purified IgG in PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide.
WB, IHC, and ICC · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.Calcium channel, voltage-dependent, β1 subunit, also known as CACNB1, is a human gene. Stability:1 year. The protein encoded by this gene belongs to the calcium channel β subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the α1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Storage:-20°C.
Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential.

More about: Buy Cavβ1 Calcium Channel Monoclonal Antibody 
Read more>> Raw pharmaceutical materials

What is Cytochrome b5 (human)

Cytochromes b5 are ubiquitous electron transport hemoproteins found in animals, plants, fungi and purple phototrophic bacteria. The microsomal and mitochondrial variants are membrane-bound, while bacterial and those from erythrocytes and other animal tissues are water-soluble. Cytochromes b5 (cyt b5) are ubiquitous electron transport proteins found in animals, plants and fungi. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.
The family of cytochrome b5-like proteins includes (besides cytochrome b5 itself) hemoprotein domains covalently associated with other redox domains in flavocytochrome cytochrome b2 (L-lactate dehydrogenase; EC 1.1.2.3), sulfite oxidase (EC 1.8.3.1), plant and fungal nitrate reductases (EC 1.7.1.1, EC 1.7.1.2, EC 1.7.1.3), and plant and fungal cytochrome b5/acyl lipid desaturase fusion proteins. The enzyme from the control LCL (c 252/B 95) was found to be immunologically related to the human soluble erythrocyte cytochrome b5 reductase, indicating that it is the product of the same gene: the DIA1 (diaphorase) locus.
Cytochrome b5 is a membrane-bound member of the cytochrome b family. A heme protein that functions as an electron carrier for many membrane-bound oxygenases, cytochrome b5 possesses two heme groups, which are not covalently attached to the protein. The LCL derived from one patient with the type I disease and two patients with the type II disease were investigated.l In the former the defect was expressed to a lesser degree than in the cases with mental retardation in which the defect was much pronounced, and involved both the mitochondrial and the microsomal fraction.
More about: Buy Cytochrome b5 (human)
Read more>> Raw pharmaceutical materials

How to Buy Cytochrome P450 1B1 (human) Yeast Reductase

Human cytochrome P450 1B1 (CYP1B1) is found mainly in extrahepatic tissues and is overexpressed in a variety of human tumors. The inhibition of recombinant human CYP1B1 by 2,2′,4,6′-tetramethoxystilbene (TMS) was investigated using either the Escherichia coli membranes of recombinant human CYP1B1 coexpressed with human NADPH-P450 reductase or using purified enzyme. 2,2′,4,6′-TMS showed potent and selective inhibition of ethoxyresorufin O-deethylation (EROD) activity of CYP1B1 with IC50 values of 2 nM.
Metabolic activation of 17β-estradiol (E2) to 4-hydroxy E2 by CYP1B1 has been postulated to be an important factor in mammary carcinogenesis. The inhibition of recombinant human CYP1B1 by 2,2′,4,6′-tetramethoxystilbene (TMS) was investigated using either the Escherichia coli membranes of recombinant human CYP1B1 coexpressed with human NADPH-P450 reductase or using purified enzyme. 2,2′,4,6′-TMS showed potent and selective inhibition of ethoxyresorufin O-deethylation (EROD) activity of CYP1B1 with IC50 values of 2 nM. 2,2′,4,6′-TMS exhibited 175-fold selectivity for CYP1B1 over CYP1A1 (IC50, 350 nM) and 85-fold selectivity for CYP1B1 over CYP1A2 (IC50, 170 nM). 2,2′,4,6′-TMS exhibited 175-fold selectivity for CYP1B1 over CYP1A1 (IC50, 350 nM) and 85-fold selectivity for CYP1B1 over CYP1A2 (IC50, 170 nM). However, inhibition of human NADPH-P450 reductase activity by 2,2′,4,6′-TMS was negligible. The modes of inhibition by 2,2′,4,6′-TMS were noncompetitive for CYP1A1 and CYP1B1.
However, inhibition of human NADPH-P450 reductase activity by 2,2′,4,6′-TMS was negligible. The modes of inhibition by 2,2′,4,6′-TMS were noncompetitive for CYP1A1 and CYP1B1.

More about: Buy Cytochrome P450 1B1 (human) Yeast Reductase
Read more>>  Raw pharmaceutical materials

S-Glutathionylated Protein Detection Kit for Sale

S-Glutathionylated Protein Detection Kit provides a convenient method for the direct visualization of S-glutathionylated proteins in whole (permeabilized) cells by flow cytometry and microscopy as well as avidin overlay analysis.  This cell-based assay starts with the modification of protein free-thiols groups followed by enzymatic cleavage of any protein-S-glutathione (PSSG) adducts present in the sample. Caymans S-Glutathionylated Protein Detection Assay Kit provides a convenient method for the direct visualization of S-glutathionylated proteins in whole (permeabilized) cells by flow cytometry and microscopy as well as avidin overlay analysis.
Biotinylation of the newly-formed protein free-thiols provides the basis for visualization using streptavidin-based colorimetric or fluorescence detection. Reagents are provided to test three sets of 10 samples (most convenient) or up to thirty samples total at once if desired. Mixed protein glutathionyl disulfides are a post translational protein modification of growing interest. Protein S-glutathionylation (PSSG) may modify the activity of a large number of cell proteins, including metabolic, structural, cytoskeletal, and signaling proteins.  Cayman’s S-Glutathionylated Protein Detection Assay Kit provides a convenient method for the direct visualization of S-glutathionylated proteins in whole (permeabilized) cells by flow cytometry and microscopy as well as avidin overlay analysis.
Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH is involved in maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.  PSSG detection methods can employ GSH adduct antibodies, GSH derivatives, and differential labeling systems based on the “Biotin-Switch” method.This cell-based assay starts with the modification of protein free-thiols groups followed by enzymatic cleavage of any protein-S-glutathione (PSSG) adducts present in the sample.
More about: S-Glutathionylated Protein Detection Kit Suppliers
Read more>> Raw pharmaceutical materials

Where to Buy Insulin (rat) EIA Kit

The Rat Insulin ELISA was re-optimized and improved during 2010. Impairment in insulin secretion and/or downstream signaling results in the deregulation of carbohydrate and lipid metabolism, a hallmark of diabetes. An increase or decrease in the level of insulin is pathophysiologically linked with type 2 or type 1 diabetes. The kit is still based on the same highly specific monoclonal antibodies with insignificant or no cross-reactivity to C-peptide or proinsulin. 
Apart from glucose homeostasis, the hormone has growth-stimulating effects and has been directly and/or indirectly involved in the pathogenesis of several diseases, such as poly cystic ovary disease (PCOD), obesity, atherosclerosis, prostatic hyperplasia, hypertension, and cancer.
Insulin is a polypeptide hormone with molecular weight of 6 kDa, composed of two peptides chains, A and B, cross-linked by two disulfide bonds and synthesized by the β cells of the islets of Langherans of the pancreas. It plays a critical role in several physiological processes, such as lipid metabolism, cell proliferation, differentiation, aging, reproduction and growth (1, 3). Insulin influences most of the metabolic functions of the body.
To investigate the physiological role of insulin and its involvement in the pathogenesis of different diseases, the estimation of insulin level is required. Its best known action is to lower the blood glucose concentration by increasing the rate at which glucose is converted to glycogen in the liver and muscle, and to fat in adipose tissue, by stimulating the rate of glucose metabolism, and by depressing gluconeogenesis.
More about: Insulin (rat) EIA Kit Sale
Read more>> Raw pharmaceutical materials

Akt3 Monoclonal Antibody (Clone 66C1247.1) for Sale

WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). Akt3 Antibody detects endogenous levels of total Akt3, but does not recognize the truncated form of rat Akt3. For research use only and not for use in diagnostic or therapeutic procedures. Storage at -20°C.
The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3-kinase and Akt/PKB kinase activity. The antibody does not cross-react with recombinant Akt1 or Akt2. Stability:1 year
There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein.
Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. This is a monoclonal antibody. Clone 66C1247.1. Akt/PKB phosphorylation is critical for its activity.
More about: Buy Akt3 Monoclonal Antibody (Clone 66C1247.1)
Read more>> Raw pharmaceutical materials

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central
role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by
phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene
underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal
pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This
inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg
AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to
AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular
processes such as glucose metabolism, cell proliferation, apoptosis, transcription and
cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and
Akt3 kinase activity.
The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD)
sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell
permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
More about: Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers
Read more>> Raw pharmaceutical materials

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set for Sale

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg

AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and Akt3 kinase activity. The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
More about: Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers
Read more>> www.medicine-raw-materials.com

Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7) for Sale

Porduct Name: Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7)Stability: 1 year
Storage: -20°C
Formulation:
100 ?g of protein G-purified IgG in 100 ?l PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt
Description: WB, IHC, ICC, and IF · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the a1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role.
Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
More about: Cavβ4 Calcium Channel Monoclonal Antibody Sale
Read more>>  www.medicine-raw-materials.com

Cytochrome P450 3A5 (human) for Sale

Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
The 5′-terminus of a P450 3A5 cDNA was modified for optimal expression in Escherichia coli using the vector pCW, by aligning the MALLLAVFL N-terminal sequence of recombinant bovine P450 17A (H. J. Barnes, M. P. Arlotto, and M. R. Waterman, (1991) Proc. Natl. Acad. Sci. USA 88, 5597-5601) to the 3A5 cDNA. Cytochromes P450 are a group of heme-thiolate monooxygenases.
Purified P450 3A5 was active in nifedipine oxidation, testosterone 6β-hydroxylation, aflatoxin 3α-hydroxylation and 8,9-epoxidation, N-ethylmorphine N-demethylation, erythromycin N-demethylation, and d-benzphetamine N-demethylation. Enhanced midazolam hydroxylation and cyclosporin metabolism occur in an in vitro P450 3A5 system and in liver microsomes expressing P450 3A5 in the presence of thalidomide. The reconstitution of nifedipine oxidation, testosterone 6β-hydroxylation, and the aflatoxin oxidation activities showed dependence upon the presence of cytochrome b5, divalent cations, phospholipid mixtures, glutathione, and cholate similar to that previously found for purified P450 3A4.
Synonyms: CYP3A5 HR
Stability: 2 months
Storage: -80°C
More about: buy  Cytochrome P450 3A5 (human)
Read more>>  www.medicine-raw-materials.com

How to Buy NMDA Receptor NR2B Subunit Polyclonal Antibody

NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy. and ischemic neuronal cell death.Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
Stability: 1 year
Storage: -20°C
Formulation: Affinity-purified IgG
Application Notes
Specific for the ~180k NR2B subunit of the NMDA Receptor. No reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.
More about: NMDA Receptor NR2B Subunit Polyclonal Antibody  Sale
Read more>>  www.medicine-raw-materials.com

What is TBARS Assay Kit

TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates and cell lysates.
Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically following its controlled reaction with thiobarbituric acid. Cayman’s TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates, and cell lysates.
Stability: 1 year
Storage: 4°C
Synonyms: Thiobarbituric Acid Reactive Substances Assay Kit
The measurement of these 'Thiobarbituric Acid Reactive Substances' (TBARS) is a well-established method for screening and monitoring lipid peroxidation. Modifications of the TBARS assay has been used to evaluate a wide range of samples that include human and animal tissues and fluids, drugs and foods. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation.
More about: TBARS Assay Kit Sale
Read more>> www.medicine-raw-materials.com

The Usae of TBARS Assay Kit

TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates and cell lysates. The measurement of these 'Thiobarbituric Acid Reactive Substances' (TBARS) is a well-established method for screening and monitoring lipid peroxidation. Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Cayman’s TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates, and cell lysates.
Modifications of the TBARS assay has been used to evaluate a wide range of samples that include human and animal tissues and fluids, drugs and foods. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation. Storage:4°C.  Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically following its controlled reaction with thiobarbituric acid. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation.

More about: buy TBARS Assay Kit
Read more>>  www.medicine-raw-materials.com

Waht is Donepezil

Donepezil appears as a crystalline solid. It is a reversible acetylcholinesterase inhibitor used to treat dementia. Dementia is a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may causecause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
CAS Number:120014-06-4
Molecular Formula:C24H29NO3
Formula Weight:379.5g/mol
Purity:≥95%
Stability:2 years
Storage:-20°C

Donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. That readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system. Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. This medication may be prescribed for other uses. It is effective in controlled clinical trials are 5 and 10 mg administered once a day, usually in the evening.

More about:  Donepezil sale
Read more>>

Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7) for Sale

Formulation of Cavβ4 Calcium Channel Monoclonal Antibody:
100 ?g of protein G-purified IgG in 100 ?l PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt. Storage:-20°C.
WB, IHC, ICC, and IF · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the a1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.

More about: Cavβ4 Calcium Channel Monoclonal Antibody use

Read more: www.medicine-raw-materials.com

Where to get Fatty Acid Screening Library (96-well)

Fatty Acid Screening Library (96-well) is  Many free fatty acids and their metabolites serve as precursors to important signaling systems (e.g. prostaglandins), act directly as receptor ligands or enzyme inhibitors, and have pro- or anti-atherosclerotic and anti-hypertensive properties through mechanisms that are still being characterized.  
Some unusual fatty acids, like 9-thiastearic acid, 2-hydroxymyristic acid, AUDA, and CUDA are Also included in it.
It includes 84 of the most commonly-ordered fatty acids, including palmitic acids, stearic, α- and γ-linolenic, oleic, and arachidonic, linoleic, eicosapentaenoic. It contains a variety of fatty acids with diverse biological activities. Therefore, a diverse set of fatty acids can be a source of compounds for receptor de-orphaning, high content screening and inhibitor screening.
KFO France Co. Ltd. is biotech laboratories founded in France and China in 2001, KFO focuses on research and development of medicine raw materials. We are committed to assisting customers worldwide with their unique needs by providing them with comprehensive and professional service, enjoying a good reputation among our business partners and customers for high quality products, excellent after sales services, competitive prices and prompt shipping.

More about: buy Fatty Acid Screening Library (96-well)
Read more: www.medicine-raw-materials.com

What is P-Glycoprotein Drug Interaction Assay Kit

P-Glycoprotein (P-gp) is an active plasma membrane transporter involved in drug pharmacokinetics and cellular detoxification. P-gp exhibits a high drug-dependent ATP hydrolysis activity that is a reflection of its drug transport ability. The test of drug stimulation or inhibition of ATPase activity may be used to screen the potential drug interaction with P-gp. Storage:-20°C. P-gp ATPase activity is measured by a spectrophotometric method based on continuous monitoring of ADP formation in the vesicle suspension medium in a 96 well plate format. This assay provides an in vitro screening method for testing drug interaction with P-gp based on the study of modulation of basal or induced ATPase activity from enriched P-gp membrane vesicle preparations. Data are analyzed by comparing the variation of the basal or stimulated activities to reference activities.

More about: Buy P-Glycoprotein Drug Interaction Assay Kit
Read more: http://www.medicine-raw-materials.com/

How to Get Monoacylglycerol Lipase Inhibitor Screening Assay Kit

Product name: Monoacylglycerol Lipase Inhibitor Screening Assay Kit
Stability:6 months
Storage:-80°C
Description:the main enzyme responsible for the inactivation of this monoglyceride is another serine hydrolase, MAGL. Finding inhibitors to these endocannabinoid hydrolases could offer another approach in the treatment of pain, obesity, and various neurological diseases, where higher endocannabinoid activity would be beneficial. An advantage of such enzyme inhibition over direct cannabinoid agonists could result in higher selectivity, as it would increase activity of the endocannabinoid system only at sites where on-going production of endocannabinoids is taking place.

Read more: http://www.medicine-raw-materials.com/

GSK264220A for Sale

Product name: GSK264220A
CAS:685506-42-7
Molecular Formula:C17H21N3O4S
Formula Weight:363.4g/mol
Description:Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC50 = 16 nM). Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease.
Purity:≥98%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid


Read more: http://www.medicine-raw-materials.com/

Rapamycin for Sale

Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.
Purity:≥98%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid

Read more: http://www.medicine-raw-materials.com/

Valproic Acid (sodium salt) for Sale

Valproic acid is an analog of the natural fatty acid valeric acid. The sodium salt of valproic acid has long been used as an anticonvulsant to prevent many kinds of seizures. It is an inhibitor of histone deacetylases (HDACs), inhibiting Class I HDACs with an IC50 of ~ 2 mM. Valproic acid also inhibits glycogen synthase kinase (GSK3) and depletes cellular inositol-1,4,5-trisphosphate (IP3). Because of these actions, valproic acid shows promise in combination therapy for cancer  and in treating Alzheimer’s disease. Valproic acid (1 mM) also has pronounced effects on stem cell differentiation and self-renewal.
Purity: ≥95%
Stability: 2 years
Storage: -20°C
Formulation: A crystalline solid

Read more: http://www.medicine-raw-materials.com/

How to Buy L-655,240

The lipid mediator thromboxane (TX)A2 plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein-coupled receptor, referred to as the TXA2 receptor or TP. Two isoforms, TPα and TPβ, are produced from a single gene, differ in their carboxyl termini, and form homo- and hetero-oligomers. While both isoforms signal through similar pathways, they differ in the modulation by certain agonists. L-655,240 is a potent antagonist of the TP receptor in vitro (IC50 = 7 nM) It also is effective at blocking TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Whether the two TP isoforms differ in their sensitivity to L-655,240 is not known.

Read more: http://www.medicine-raw-materials.com/

How to Buy IM-54

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase
Purity:≥95%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid
CAS:861891-50-1
Molecular Formula:C19H23N3O2
Formula Weight:325.4g/mol


Read more: Raw pharmaceutical materials