What is Sphingosine Kinase 2 (human recombinant) used for?

Formulation:
10 µg in 25 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, 0.05% Tween 20, 50% glycerol, and 3mM DTT
Description of Sphingosine Kinase 2 (human recombinant)
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate sphingolipid D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, have been identified and characterized from mammalian cells. SKs, through the formation of S1P, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis, and vascular maturation. Thus SPHKs are potential therapeutic targets for the control of cancer, inflammation, and other diseases.
Purity:>80% by SDS-PAGE
Human Sphingosine kinase 2
(GenBank Accession No. AF245447), full
length with N-terminal His tag, MW=69.5 kDa,
expressed in a Baculovirus infected Sf9 cell
expression system.
Application
Useful for the study of enzyme kinetics,
screening inhibitors, and selectivity
profiling.
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