About Ephedrine Hydrochlorid

Ephedrine hydrochlorid is a white needle crystal or crystalline powder, is ephedrine hydrochloride. Significantly increased after taking ephedrine excitement level athletes, the athletes I have great effects. Therefore, these drugs are strictly prohibited by the IOC doping. Meanwhile, ephedrine hydrochloride is also an important raw material for the manufacture of methamphetamine, has been incorporated into precursor chemicals management. Because illegal trading, hedging compound preparation containing ephedrine class manufacturing narcotics have occurred, now containing ephedrine hydrochloride pharmaceutical preparations, has selective agonist for the β replaced.

Application:

Clinical application:
Ephedrine hydrochlorid as adrenergic drugs, can be excited sympathetic, can be used for bronchial asthma, whooping cough, hay fever and other allergic diseases, but also against spinal anesthesia caused by reduced blood pressure, dilate the pupils, but also for myasthenia gravis, dysmenorrhea and other diseases, but also for the central nervous system stimulants.
Clinical with its treatment of bronchial asthma and various causes of hypotension, especially subarachnoid anesthesia and epidural anesthesia induced hypotension. Also used to eliminate intranasal mucosal congestion. Mouse oral LD ​​↓ 50 to 400mg/kg.
Illegal Applications:
It is a synthetic amphetamine-type drugs is the main raw material for production of methamphetamine. Since most cold medications containing ephedrine ingredients that may be purchased for the extraction of a large number of criminals manufacture of drugs. The drugstore containing ephedrine new Contac, white with black, day and night one hundred enjoin dozens of common cold, cough and asthma drugs limited sales, purchases per person may not more than five minimum retail packaging.

Pharmacological effects:

The role of the nervous system:
Central nervous system stimulant ephedrine was stronger than adrenaline. Excitatory cortical and subcortical center, making spirits; barbiturate hypnotic time can be shortened, also excited midbrain, medullary respiratory center and vasomotor center.
The role of the cardiovascular system:
(A) The role of the heart: the heart stimulant ephedrine. Ephedrine myocardial contractility, cardiac output increases.
(2) the blood vessels: ephedrine coronary artery, brain, muscle vasodilation, increased traffic; the kidney, spleen and other organs and skin, mucosal vasoconstriction, blood flow is reduced.
(3) effect on blood pressure: systolic and diastolic blood pressure often caused by ephedrine increased pulse pressure. Pressor effect of its slow and long lasting.
Effect on smooth muscle:
(A) the impact of ephedrine on bronchial smooth muscle relaxant effect on bronchial smooth muscle weaker than adrenaline and lasting.
(2) the deltoid muscle of the bladder and the sphincter of the bladder ephedrine can increase the tension of the deltoid muscle and sphincter. Can reduce the frequency of urination, urinary retention generated a sufficient amount, effective for children with enuresis.
Effect on metabolism:
Ephedrine increase metabolism. Antipyretic, antiviral ephedrine can induce sweating.
Other effects:
Ephedrine on skeletal muscle has anti-fatigue effect, can promote curare inhibited neuromuscular transmission, can be used in the treatment of myasthenia gravis. Ephedrine also increase blood sugar, shrink the spleen, increased red blood cell and so on. Ephedrine on gastrointestinal secretion typically exhibit suppressed. Skeletal muscle fatigue can also make a significant and lasting tension to rise, as adrenergic drugs, both α and β receptor stimulant effect similar to adrenaline, but milder. There relaxation of bronchial smooth muscle, contraction of blood vessels, and other central excitatory effect. The product of the pressor effect is weak, but more lasting vasoconstriction, but no post-dilatation.

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From:Advanced Chemicals