Administration of cefodizime 1 or 2g intravenously as a individual dosage to
advantageous volunteers resulted in aiguille serum cefodizime concentrations
(Cmax) of 215 and 394 mg/L, respectively; Cmax was dose-proportional over this
range. Intravenous infusions and intramuscular injections of cefodizime 1g resulted in aiguille serum concentrations
of 124.1 mg/L and 59.6 to 75.2 mg/L, respectively. Bioavailability of cefodizime
afterwards intramuscular administering is 90 to 100%. Cefodizime is about 81%
claret protein apprenticed (primarily to albumin), and distributes into
abounding physique tissues and fluids accouterment concentrations aloft the
minimum inhibitory assimilation (MIC) of affected bacilli aural 2 to 3 hours of
administering and for several hours thereafter. Cefodizime is primarily alone
by glomerular filtration and to a bottom admeasurement by tubular secretion,
with the majority of the biologic excreted banausic in the urine in the
aboriginal 12 hours afterwards biologic administration. Concomitant
administering of probenecid to advantageous volunteers decreases cefodizime
abolishment by 30%. In patients with astute deepening of abiding bronchitis the
terminal appearance abolishment half-life of cefodizime has been appear to be
4.8 to 5.0 hours, and the abolishment half-life is abiding 2-fold in patients
with astringent renal crime Systemic assimilation of cefodizime from the
intraperitoneal aqueous is capricious and serum abolishment is abiding in
patients ability connected peritoneal dialysis. Cefodizime is removed from the
systemic apportionment by haemodialysis with a terminal appearance abolishment
half-life of 3.5 hours, agnate to that in patients with accustomed renal
function.
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