What is Andrographolide?

Andrographolide is a almighty anticancer and anti-inflammatory abettor abandoned from the bulb Andrographis paniculata. It is begin to be cytotoxic adjoin assorted blight corpuscle curve (in vitro) and aswell appear to act as an anti-inflammatory abettor by interfering with NF-κB protein. Andrographolide induced college allotment of apoptosis in glutathione-depleted lymphoma corpuscle lines. Andrographolide was aswell appear to anatomy dehydrated adduct with bargain glutathione at 50° C. On the base of these observations, the advancing assay of andrographolide with its ambition protein (NF-κB/p50) and its proposed anti-target protein (glutathione S-transferase) was agitated out. Advancing assay predicted the best accepted affectation of andrographolide atom in the alive website of NF-κB and glutathione S-transferase proteins. Here we address that the furan ring of andrographolide interacts with cysteine 59 of NF-κB/p50 and thereby inhibiting the protein action. Advancing studies showed the andrographolide bounden to the H-site of glutathione S-transferase agitator which resembles the behaviour of affected xenobiotics inactivated by glutathione S-transferase enzyme. Andrographolide obeys Pfizer's aphorism but drug-likeness amount for andrographolide is begin to be abrogating as the atom showed low biologic score. Hence, inactivation by glutathione S-transferase and low biologic account could possibly be the affidavit to accomplish andrographolide abeyant in analytic trial.