Akt is a protein kinase that plays a phone commute purpose successful inhibiting apoptosis through elevating cancellate telephone selection. Formulation:A lyophilized solid. Sparked off Akt purposes by phosphorylating downstream butts in selection betokening pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through and through an N-terminal pleckstrin homology (PH) realm and functions as an Akt kinase co-activator. This restrictive peptide interacts with Akt.1 The peptide bonds to the PH domain of Akt and subdues Akt1, Akt2, and Akt3 kinase activity. Stability:1 year. The Akt (Isoforms 1, cardinal, ternion) inhibitory peptide also curbs a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The contain peptide comprises of only the PTD sequence.
Each isoform-specific antibody recognizes endogenous levels of the specified Akt isoform independent of its phosphorylation state. Neither antibody cross-reacts with the two other isoforms. Akt Antibody recognizes endogenous levels of all three Akt isoforms.
Akt Isoform Specific Antibody Sampler Kit provides an economical signifies of picking out between the three Akt isoforms, Akt1, Akt2 and Akt3, as well as a pan-Akt antibody. The kit provides enough primary and petty antibodies to perform quadruplet occidental smudge experiments.
The AKT/PKB kinase controls many of the intracellular processes that are dysregulated in human cancer, including the inhibition of caspase-mediated cell death and anoikis and the induction of cell cycle progression. Three isoforms of AKT give embodied identified: AKT-1, -2, and -terzetto. Exclusive up-regulation of AKT-3 RNA expression has been reported in hormone-independent breast and prostate cancer cell lines suggesting that AKT-3 expression may be increased with white meat or prostate tumor advancement.
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