Prostaglandin E2 is one of the primary prostaglandins formed from the coupled metabolism of arachidonic acid by the cyclooxygenases (COX-1 and COX-2) and PGE synthases (microsomal and/or cytosolic). Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. Cayman Chemicals PGE2 Fluorescence Polarization Immunoassay (FPIA) - Green is a break-through method for rapid, high-throughput screening of PGE2 samples. It is now possible to rapidly analyze samples and increase the rate of lead compound identification without the time-consuming incubation, washing, and development steps of a solid phase EIA.This FPIA is a homogenous, single-step assay which is easily adaptable to robotic assay systems. Simply mix the sample or standard with the assay cocktail, incubate at least 60 minutes, and read the plate whenever you are ready. Each kit contains FPIA reagent, buffer concentrate (10X), standard, 384 well plate, foil plate cover, and complete instructions.
The naturally occurring prostaglandin E2 (PGE2) is known in medicine as dinoprostone. It has important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever.
Prostaglandin E2 is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.), Propess (by Ferring Pharmaceuticals) and Glandin (by Nabiqasim Pharmaceuticals Pakistan) as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.
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