Akt3 Monoclonal Antibody (Clone 66C1247.1) for Sale

WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). Akt3 Antibody detects endogenous levels of total Akt3, but does not recognize the truncated form of rat Akt3. For research use only and not for use in diagnostic or therapeutic procedures. Storage at -20°C.
The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3-kinase and Akt/PKB kinase activity. The antibody does not cross-react with recombinant Akt1 or Akt2. Stability:1 year
There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein.
Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. This is a monoclonal antibody. Clone 66C1247.1. Akt/PKB phosphorylation is critical for its activity.
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Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central
role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by
phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene
underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal
pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This
inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg
AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to
AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular
processes such as glucose metabolism, cell proliferation, apoptosis, transcription and
cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and
Akt3 kinase activity.
The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD)
sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell
permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
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Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set for Sale

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg

AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and Akt3 kinase activity. The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
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Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7) for Sale

Porduct Name: Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7)Stability: 1 year
Storage: -20°C
Formulation:
100 ?g of protein G-purified IgG in 100 ?l PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt
Description: WB, IHC, ICC, and IF · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the a1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role.
Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
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Cytochrome P450 3A5 (human) for Sale

Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
The 5′-terminus of a P450 3A5 cDNA was modified for optimal expression in Escherichia coli using the vector pCW, by aligning the MALLLAVFL N-terminal sequence of recombinant bovine P450 17A (H. J. Barnes, M. P. Arlotto, and M. R. Waterman, (1991) Proc. Natl. Acad. Sci. USA 88, 5597-5601) to the 3A5 cDNA. Cytochromes P450 are a group of heme-thiolate monooxygenases.
Purified P450 3A5 was active in nifedipine oxidation, testosterone 6β-hydroxylation, aflatoxin 3α-hydroxylation and 8,9-epoxidation, N-ethylmorphine N-demethylation, erythromycin N-demethylation, and d-benzphetamine N-demethylation. Enhanced midazolam hydroxylation and cyclosporin metabolism occur in an in vitro P450 3A5 system and in liver microsomes expressing P450 3A5 in the presence of thalidomide. The reconstitution of nifedipine oxidation, testosterone 6β-hydroxylation, and the aflatoxin oxidation activities showed dependence upon the presence of cytochrome b5, divalent cations, phospholipid mixtures, glutathione, and cholate similar to that previously found for purified P450 3A4.
Synonyms: CYP3A5 HR
Stability: 2 months
Storage: -80°C
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How to Buy NMDA Receptor NR2B Subunit Polyclonal Antibody

NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy. and ischemic neuronal cell death.Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
Stability: 1 year
Storage: -20°C
Formulation: Affinity-purified IgG
Application Notes
Specific for the ~180k NR2B subunit of the NMDA Receptor. No reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.
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What is TBARS Assay Kit

TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates and cell lysates.
Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically following its controlled reaction with thiobarbituric acid. Cayman’s TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates, and cell lysates.
Stability: 1 year
Storage: 4°C
Synonyms: Thiobarbituric Acid Reactive Substances Assay Kit
The measurement of these 'Thiobarbituric Acid Reactive Substances' (TBARS) is a well-established method for screening and monitoring lipid peroxidation. Modifications of the TBARS assay has been used to evaluate a wide range of samples that include human and animal tissues and fluids, drugs and foods. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation.
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