WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). Akt3 Antibody detects endogenous levels of total Akt3, but does not recognize the truncated form of rat Akt3. For research use only and not for use in diagnostic or therapeutic procedures. Storage at -20°C.
The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3-kinase and Akt/PKB kinase activity. The antibody does not cross-react with recombinant Akt1 or Akt2. Stability:1 year
There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein.
Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. This is a monoclonal antibody. Clone 66C1247.1. Akt/PKB phosphorylation is critical for its activity.
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ReplyDeleteThanks for providing these useful tips over here. Monoclonal antibodies are typically made by fusing myeloma cells with the spleen cells from a mouse that has been immunized with the desired antigen. These antibodies are then used to specifically destroy the tumor cells with the radioactivity or toxic substance...
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