Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central
role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by
phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene
underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal
pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This
inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg
AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to
AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular
processes such as glucose metabolism, cell proliferation, apoptosis, transcription and
cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and
Akt3 kinase activity.
The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD)
sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell
permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
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