Medical uses of Hexamethylenetetramine

Hexamethylenetetramine is a heterocyclic amoebic admixture with the blueprint (CH2)6N4. This white apparent admixture is awful acrid in baptize and arctic amoebic solvents. It has a cage-like anatomy agnate to adamantane. It is advantageous in the amalgam of added actinic compounds, e.g. plastics, pharmaceuticals, elastic additives. It sublimes in a exhaustion at 280 °C.
Applications
The capital use of Hexamethylenetetramine is in the assembly of arenaceous or aqueous affairs of phenolic resins and phenolic adhesive moulding compounds, area it is added as a hardening component. These articles are acclimated as binders, e.g. in anchor and clamp linings, annoying products, non-woven textiles, formed locations produced by moulding processes, and fireproof materials.
Medical uses
As the mandelic acerbic alkali (generic methenamine mandelate tablets, USP) it is acclimated for the analysis of urinary amplitude infection: hexamethyltetramine ("methenamine") decomposes at an acerbic pH to formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acerbic adds to this effect. Urinary acidity is about ensured by co-administering vitamin C (ascorbic acid) or ammonium chloride. Its use had briefly been bargain in the backward 1990s, due to adverse furnishings (notably chemically-induced hemorrhagic cystitis in overdose), but its use has now been reapproved because of the prevalence of antibacterial attrition to added frequently acclimated drugs. This biologic is decidedly acceptable for abiding antibacterial analysis of urinary amplitude infection, because bacilli do not advance attrition to formaldehyde: however, it should not be acclimated in the attendance of renal insufficiency.
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