Monosodium phosphate (NaH2PO4), also known as anhydrous monobasic sodium phosphate and sodium dihydrogen phosphate, is a chemical compound of sodium with a phosphate counterion. It is used as a laxative and, in combination with other sodium phosphates, as a pH buffer.
The pKa is 6.8-7.20 (depending on the physicochemical characteristics during pKa determination). The sodium chloride equivalent value, or E-Value, is 0.49. It is soluble in 4.5 parts water. It is most commonly available as colorless crystals or a white powder. It is insoluble in alcohol. It is also formed when a sodium halide compound reacts with phosphoric acid.
Oral Sodium phosphates for bowel preparation for colonoscopy may in some individuals carry a risk of kidney injury under the form of phosphate nephropathy. There are several oral phosphate formulations which are prepared extemporaneously. Oral phosphate prep drugs have been withdrawn in the United States, although evidence of causality is equivocal. Since safe and effective replacements for phosphate puratives are available, several authors have recommended general disuse of oral phosphates.
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