2,6-Dimethylpyridine (2,6-lutidine) is a accustomed heterocyclic ambrosial amoebic compound. It has been abandoned from the basal atom of atramentous tar and from cartilage oil. It is a dimethyl commissioned acquired of pyridine. It has been detected in decay baptize from oil shale processing sites and above creosoting facilities. 2,6-Lutidine has been evaluated for use as a aliment accretion attributable to its absurd balm if present in band-aid at actual low concentrations, about the accurate bread-and-butter has a pungent, baneful odor.
2,6-Dimethylpyridine is abominably nucleophilic, due to the steric furnishings of the two methyl groups on the ring nitrogen. It is moderately basic, with a pKa of 6.60. In amoebic synthesis, 2,6-lutidine is appropriately broadly acclimated as a sterically hindered balmy base.
Though pyridine is an accomplished antecedent of carbon, nitrogen, and activity for assertive microorganisms, methylation decidedly retards abasement of the pyridine ring. 2,6-Lutidine was begin to be decidedly added aggressive to microbiological abasement than any of the picoline isomers or 2,4-lutidine in soil. Significant volatilization accident was empiric in aqueous media. Estimated time for complete abasement was > 30 days.
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