Akt3 Monoclonal Antibody (Clone 66C1247.1) for Sale

WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). Akt3 Antibody detects endogenous levels of total Akt3, but does not recognize the truncated form of rat Akt3. For research use only and not for use in diagnostic or therapeutic procedures. Storage at -20°C.
The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3-kinase and Akt/PKB kinase activity. The antibody does not cross-react with recombinant Akt1 or Akt2. Stability:1 year
There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein.
Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. This is a monoclonal antibody. Clone 66C1247.1. Akt/PKB phosphorylation is critical for its activity.
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Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set Suppliers

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central
role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by
phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene
underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal
pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This
inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg
AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to
AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular
processes such as glucose metabolism, cell proliferation, apoptosis, transcription and
cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and
Akt3 kinase activity.
The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD)
sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell
permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
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Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set for Sale

Akt (Isoforms 1, 2, 3) Inhibitory Peptide Set  is a protein kinase that plays a central role in inhibiting apoptosis through promoting cell survival. Activated Akt functions by phosphorylating downstream targets in survival signaling pathways. TCL1 (a proto-oncogene underlying human T-cell prolymphocytic leukemia) interacts with Akt through an N-terminal pleckstrin homology (PH) domain and functions as an Akt kinase co-activator. This inhibitory peptide interacts with Akt.1.
Product Name: Akt (Isoforms-1-2-3) Inhibitory Peptide Set
Molecule Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Original Item Name: AKT (Isoforms 1,2,3) Inhibitory Peptide Set
Quantity: 2 mg

AKT (Isoforms 1,2,3) Inhibitory Peptide Set functions as a TCL1 PH decoy by binding to AKT.
Akt, is a serine/threonine protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration. The peptide binds to the PH domain of Akt and inhibits Akt1, Akt2, and Akt3 kinase activity. The Akt (Isoforms 1, 2, 3) inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2. The control peptide consists of only the PTD sequence.
Formulation: A lyophilized solid; Stability:1 year; Storage:-20°C
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Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7) for Sale

Porduct Name: Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7)Stability: 1 year
Storage: -20°C
Formulation:
100 ?g of protein G-purified IgG in 100 ?l PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt
Description: WB, IHC, ICC, and IF · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the a1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role.
Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
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Cytochrome P450 3A5 (human) for Sale

Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
The 5′-terminus of a P450 3A5 cDNA was modified for optimal expression in Escherichia coli using the vector pCW, by aligning the MALLLAVFL N-terminal sequence of recombinant bovine P450 17A (H. J. Barnes, M. P. Arlotto, and M. R. Waterman, (1991) Proc. Natl. Acad. Sci. USA 88, 5597-5601) to the 3A5 cDNA. Cytochromes P450 are a group of heme-thiolate monooxygenases.
Purified P450 3A5 was active in nifedipine oxidation, testosterone 6β-hydroxylation, aflatoxin 3α-hydroxylation and 8,9-epoxidation, N-ethylmorphine N-demethylation, erythromycin N-demethylation, and d-benzphetamine N-demethylation. Enhanced midazolam hydroxylation and cyclosporin metabolism occur in an in vitro P450 3A5 system and in liver microsomes expressing P450 3A5 in the presence of thalidomide. The reconstitution of nifedipine oxidation, testosterone 6β-hydroxylation, and the aflatoxin oxidation activities showed dependence upon the presence of cytochrome b5, divalent cations, phospholipid mixtures, glutathione, and cholate similar to that previously found for purified P450 3A4.
Synonyms: CYP3A5 HR
Stability: 2 months
Storage: -80°C
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How to Buy NMDA Receptor NR2B Subunit Polyclonal Antibody

NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy. and ischemic neuronal cell death.Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
Stability: 1 year
Storage: -20°C
Formulation: Affinity-purified IgG
Application Notes
Specific for the ~180k NR2B subunit of the NMDA Receptor. No reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.
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What is TBARS Assay Kit

TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates and cell lysates.
Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically following its controlled reaction with thiobarbituric acid. Cayman’s TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates, and cell lysates.
Stability: 1 year
Storage: 4°C
Synonyms: Thiobarbituric Acid Reactive Substances Assay Kit
The measurement of these 'Thiobarbituric Acid Reactive Substances' (TBARS) is a well-established method for screening and monitoring lipid peroxidation. Modifications of the TBARS assay has been used to evaluate a wide range of samples that include human and animal tissues and fluids, drugs and foods. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation.
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The Usae of TBARS Assay Kit

TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates and cell lysates. The measurement of these 'Thiobarbituric Acid Reactive Substances' (TBARS) is a well-established method for screening and monitoring lipid peroxidation. Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Cayman’s TBARS Assay Kit provides a simple, reproducible, and standardized tool for assaying lipid peroxidation in plasma, serum, urine, tissue homogenates, and cell lysates.
Modifications of the TBARS assay has been used to evaluate a wide range of samples that include human and animal tissues and fluids, drugs and foods. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation. Storage:4°C.  Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically following its controlled reaction with thiobarbituric acid. Even though there remains a controversy cited in literature regarding the specificity of TBARS toward compounds other than MDA, it still remains the most widely employed assay used to determine lipid peroxidation.

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Waht is Donepezil

Donepezil appears as a crystalline solid. It is a reversible acetylcholinesterase inhibitor used to treat dementia. Dementia is a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may causecause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
CAS Number:120014-06-4
Molecular Formula:C24H29NO3
Formula Weight:379.5g/mol
Purity:≥95%
Stability:2 years
Storage:-20°C

Donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. That readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system. Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. This medication may be prescribed for other uses. It is effective in controlled clinical trials are 5 and 10 mg administered once a day, usually in the evening.

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Cavβ4 Calcium Channel Monoclonal Antibody (Clone S10-7) for Sale

Formulation of Cavβ4 Calcium Channel Monoclonal Antibody:
100 ?g of protein G-purified IgG in 100 ?l PBS, pH 7.4, containing 50% glycerol and 0.09% sodium salt. Storage:-20°C.
WB, IHC, ICC, and IF · Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the a1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.

More about: Cavβ4 Calcium Channel Monoclonal Antibody use

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Where to get Fatty Acid Screening Library (96-well)

Fatty Acid Screening Library (96-well) is  Many free fatty acids and their metabolites serve as precursors to important signaling systems (e.g. prostaglandins), act directly as receptor ligands or enzyme inhibitors, and have pro- or anti-atherosclerotic and anti-hypertensive properties through mechanisms that are still being characterized.  
Some unusual fatty acids, like 9-thiastearic acid, 2-hydroxymyristic acid, AUDA, and CUDA are Also included in it.
It includes 84 of the most commonly-ordered fatty acids, including palmitic acids, stearic, α- and γ-linolenic, oleic, and arachidonic, linoleic, eicosapentaenoic. It contains a variety of fatty acids with diverse biological activities. Therefore, a diverse set of fatty acids can be a source of compounds for receptor de-orphaning, high content screening and inhibitor screening.
KFO France Co. Ltd. is biotech laboratories founded in France and China in 2001, KFO focuses on research and development of medicine raw materials. We are committed to assisting customers worldwide with their unique needs by providing them with comprehensive and professional service, enjoying a good reputation among our business partners and customers for high quality products, excellent after sales services, competitive prices and prompt shipping.

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What is P-Glycoprotein Drug Interaction Assay Kit

P-Glycoprotein (P-gp) is an active plasma membrane transporter involved in drug pharmacokinetics and cellular detoxification. P-gp exhibits a high drug-dependent ATP hydrolysis activity that is a reflection of its drug transport ability. The test of drug stimulation or inhibition of ATPase activity may be used to screen the potential drug interaction with P-gp. Storage:-20°C. P-gp ATPase activity is measured by a spectrophotometric method based on continuous monitoring of ADP formation in the vesicle suspension medium in a 96 well plate format. This assay provides an in vitro screening method for testing drug interaction with P-gp based on the study of modulation of basal or induced ATPase activity from enriched P-gp membrane vesicle preparations. Data are analyzed by comparing the variation of the basal or stimulated activities to reference activities.

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How to Get Monoacylglycerol Lipase Inhibitor Screening Assay Kit

Product name: Monoacylglycerol Lipase Inhibitor Screening Assay Kit
Stability:6 months
Storage:-80°C
Description:the main enzyme responsible for the inactivation of this monoglyceride is another serine hydrolase, MAGL. Finding inhibitors to these endocannabinoid hydrolases could offer another approach in the treatment of pain, obesity, and various neurological diseases, where higher endocannabinoid activity would be beneficial. An advantage of such enzyme inhibition over direct cannabinoid agonists could result in higher selectivity, as it would increase activity of the endocannabinoid system only at sites where on-going production of endocannabinoids is taking place.

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GSK264220A for Sale

Product name: GSK264220A
CAS:685506-42-7
Molecular Formula:C17H21N3O4S
Formula Weight:363.4g/mol
Description:Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC50 = 16 nM). Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease.
Purity:≥98%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid


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Rapamycin for Sale

Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.
Purity:≥98%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid

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Valproic Acid (sodium salt) for Sale

Valproic acid is an analog of the natural fatty acid valeric acid. The sodium salt of valproic acid has long been used as an anticonvulsant to prevent many kinds of seizures. It is an inhibitor of histone deacetylases (HDACs), inhibiting Class I HDACs with an IC50 of ~ 2 mM. Valproic acid also inhibits glycogen synthase kinase (GSK3) and depletes cellular inositol-1,4,5-trisphosphate (IP3). Because of these actions, valproic acid shows promise in combination therapy for cancer  and in treating Alzheimer’s disease. Valproic acid (1 mM) also has pronounced effects on stem cell differentiation and self-renewal.
Purity: ≥95%
Stability: 2 years
Storage: -20°C
Formulation: A crystalline solid

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How to Buy L-655,240

The lipid mediator thromboxane (TX)A2 plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein-coupled receptor, referred to as the TXA2 receptor or TP. Two isoforms, TPα and TPβ, are produced from a single gene, differ in their carboxyl termini, and form homo- and hetero-oligomers. While both isoforms signal through similar pathways, they differ in the modulation by certain agonists. L-655,240 is a potent antagonist of the TP receptor in vitro (IC50 = 7 nM) It also is effective at blocking TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Whether the two TP isoforms differ in their sensitivity to L-655,240 is not known.

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How to Buy IM-54

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase
Purity:≥95%
Stability:2 years
Storage:-20°C
Formulation:A crystalline solid
CAS:861891-50-1
Molecular Formula:C19H23N3O2
Formula Weight:325.4g/mol


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