Thursday, November 17, 2011

Waht is Donepezil

Donepezil appears as a crystalline solid. It is a reversible acetylcholinesterase inhibitor used to treat dementia. Dementia is a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may causecause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
CAS Number:120014-06-4
Molecular Formula:C24H29NO3
Formula Weight:379.5g/mol
Purity:≥95%
Stability:2 years
Storage:-20°C

Donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. That readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system. Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. This medication may be prescribed for other uses. It is effective in controlled clinical trials are 5 and 10 mg administered once a day, usually in the evening.

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