The Functions of Akt3 Monoclonal Antibody

Antibodies are purified by protein A and peptide affinity chromatography.

This kinase births equalled displayed to equal stimulated of platelet-derived growth factor , insulin, and insulin-like growth factor 1 . Alternatively splice transcript variants encoding distinct isoforms have been described.

WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is convoluted in many cellular signaling pathways and acts as a transducer of many officiates originated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. They are intricate inward a all-encompassing diversity of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as comfortably as glycogen synthesis and glucose uptake.

Polyclonal antibodies are produced by inoculating beasts with a semisynthetic peptide comparable to residues of human Akt3.

Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppresser gene PTEN embodied constitute to antagonise PI3-kinase and Akt/PKB kinase activity. There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for its activity.

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