Sphingosine kinase (SPHK) is an authoritative enzyme inch the sphingolipid metabolic nerve pathway. SPHKs phosphorylate sphingolipid D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, consume embodied keyed out and characterized from mammalian cells. Thus SPHKs are potential therapeutic fair game* because the ascendence of cancer, fervor, and other diseases. On the extra helping hand, it appears to act as an intracellular second messenger, though the in dispute molecular aim(s) to which it binds within cells remains to be discovered.
In any character, a role of S1P in various functions of cells and tissues constitutes constituted, including regulation of cellular telephone survival and motility, angiogenesis, and inflammatory responses. SKs, through the formation of S1P, have been implicated incoming a diverse range of cellular litigates, including cellular telephone proliferation, apoptosis, calcium homeostasis, angiogenesis, and vascular maturation. Sphingosine kinases (SphKs) types 1 and 2, the two enzymes identified so far in mammals that produce S1P by ATP-dependent phosphorylation of sphingosine, have therefore encountered goodish occupy.
Sphingosine Kinase 2 (human recombinant) is a head group, such as phosphocholine or a carbohydrate, can now be added to the 1-OH, forming a sphingolipid, although most sphingolipids of higher eukaryotes contain further modifications of the LCB.
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